Peptide Regulation of Cell Differentiation.

Mechanism / theoretical grounding — not clinical validation.

Khavinson V, Linkova N, Diatlova A, Trofimova S. Stem Cell Rev Rep. 2020.

Organ: thymus-immune · Type: theoretical · Peptides: Epitalon, Vilon, KED, Testagen, Pancragen, Bronchogen

A 2020 catalog of short peptides proposed to direct stem-cell differentiation by sequence; KEDG is listed among immune-cell differentiators, not as a gonad peptide — a review hypothesis, not a trial.

Editorial summary of a 2020 Stem Cell Reviews and Reports article. Literature catalog of differentiation claims. Public pages cite PubMed only. Read the paper: PMID 31808038.

Methods

Narrative review. The authors collect published short peptides said to enter cells and nuclei and to influence genes of cell differentiation, grouping sequences by the tissue direction claimed. No new differentiation experiment is reported in the abstract.

Findings

Direction of induction is said to depend on peptide structure and concentration. AEDG (Epitalon) and AEDP are listed for pluripotent cells toward epidermis, mesenchyme, and nervous tissue; KE (Vilon), AED, KED, AEDG, and a longer EK polymer for neural differentiation; AEDL (Bronchogen) and KEDW (Pancragen) for lung and pancreatic cells; immune-cell differentiation is attributed to KE, DS, γ-glutamyl dipeptides, AED, KED, EDA, and KEDG (Testagen). IRW, GRGDS, and YCWSQYLCY are listed for osteogenic differentiation; KE, AEDL, and AEDG also for plant cells. Proposed routes include signaling pathways, histone contacts, methylation, and direct DNA interaction.

In this catalog KEDG is an immune-differentiation sequence, not a gonad or fertility peptide. A review list is not a stem-cell therapy protocol. Follow the PMID.