Peptides regulate expression of signaling molecules in kidney cell cultures during in vitro aging.

Khavinson VKh, Lin'kova NS, Polyakova VO, Durnova AO, Nichik TE, Kvetnoi IM. Bull Exp Biol Med. 2014.

Organ: liver-metabolic · Type: in-vitro · Peptides: AED, EDL

In aging primary kidney cultures, a calf-kidney polypeptide complex and tripeptide AED (T-31) were reported to activate cell-renewal markers, while EDL (T-35) targeted gelatinase MMP-14.

Editorial summary of a 2014 short original article in Bulletin of Experimental Biology and Medicine. Kidney epithelial culture during in-vitro aging. Public pages cite PubMed only. Read the paper: PMID 24958378.

Methods

Primary kidney cell cultures during aging, treated with a polypeptide complex isolated from calf kidney and with short peptides T-31 (AED) and T-35 (EDL). The authors measured expression of signaling molecules used as markers of cell renewal (Ki-67, p53), extracellular-matrix remodeling (MMP-14), and immune response (IL-8). Culture passages and concentrations belong in the primary text.

Findings

The authors report that the renal polypeptide complex and T-31 (AED) activate cell-renewal processes during aging of the renal epithelium, and that gelatinase MMP-14 is the target of T-35 (EDL).

This is a single short in-vitro communication. Kidney culture is not a clinical nephrology result. Follow the PMID.